Nibrin Polyclonal Antibody, 100ul[BT-AP06020] Protein Research PTM:Several N-termini have been identified

PTM:Several N-termini have been identified by direct sequencing

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase

The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5

Alternative splicing results in multiple transcript variants of AXL

and comes sterile for convenience

Nibrin Polyclonal Antibody, 100ul[BT-AP06020] Protein Research PTM:Several N-termini have been identifiedMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.