CD55 Polyclonal Antibody, 50ul[BT-AP02079] Vacuum Aspirator MAD2 is a key component

MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle

Probably involved in a neuron-specific signal transduction

leading to the dephosphorylation of Cdc2 in the late G2 phase

Defects in this gene cause Niemann-Pick type C disease| a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments

Mutations in this gene have been associated with several diseases

CD55 Polyclonal Antibody, 50ul[BT-AP02079] Vacuum Aspirator MAD2 is a key componentCOL25A1 (collagen type XXV alpha 1 chain) encodes a brain specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over expression of this collagen in mice, however, found changes in pathology